Hypodectin injection solution is used for defence against hypodermatosis and dyctiocaulosis in cattle and of edemagenosis and cephenomyosis in reindeer.
Ivermectin, the active ingredient of Hypodectin injection solution, exerts systemic action on botfly maggots, agents of dyctiocaulosis and on reindeer botfly maggots. Ivermectin stimulates secretion of gamma-aminobutyric acid by the insect’s nerve terminations and enhances its binding to the nerve cell receptors, thus causing paralysis and death of the parasite. Hypodectin injection solution has a low toxicity in mammals: LD50 in mice is 7800 mg per kg of weight upon oral administration and 19500 mg per kg of weight upon percutaneous administration.
Hypodectin injection solution belongs to class 4 of hazardous substances.
Hypodectin injection solution has a low toxicity in cattle and reindeer at therapeutic doses and causes no irritation at the site of injection.
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The product is administered singly via percutaneous route in the lower third of the neck at the dose of 3 ml to adult animals, 1.5 ml to young animals, 1 ml to reindeer weighing below 50 kg and 2 ml to reindeer weighing above 50 kg.
For early chemotherapy against hypodermatosis and dyctiocaulosis, cattle should be treated in autumn (October to November), and reindeer should be treated, depending on the zone, from August to October. All animals in the herd should undergo treatment. In March and April, upon emergence of the first larval capsules on the animals’ backs, all animals in the herd should be treated if the disease extensity exceeds 3%. In May, only affected animals should be treated. To animals affected by dyctiocaulosis, the product is administered singly in July, August or September.
The withdrawal period is 5 days. Milk from animals treated with Hypodectin injection solution may be used for food without restriction.
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